Journal article
Plasmodium berghei Hsp90 contains a natural immunogenic I-Ab-restricted antigen common to rodent and human Plasmodium species
MH Enders, G Bayarsaikhan, S Ghilas, YC Chua, R May, MN de Menezes, Z Ge, PS Tan, A Cozijnsen, V Mollard, K Yui, GI McFadden, MH Lahoud, I Caminschi, AW Purcell, RB Schittenhelm, L Beattie, WR Heath, D Fernandez-Ruiz
Current Research in Immunology | Published : 2021
Abstract
Thorough understanding of the role of CD4 T cells in immunity can be greatly assisted by the study of responses to defined specificities. This requires knowledge of Plasmodium-derived immunogenic epitopes, of which only a few have been identified, especially for the mouse C57BL/6 background. We recently developed a TCR transgenic mouse line, termed PbT-II, that produces CD4+ T cells specific for an MHC class II (I-Ab)-restricted Plasmodium epitope and is responsive to both sporozoites and blood-stage P. berghei. Here, we identify a peptide within the P. berghei heat shock protein 90 as the cognate epitope recognised by PbT-II cells. We show that C57BL/6 mice infected with P. berghei blood-st..
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Grants
Awarded by Australian Research Council